Rockville, MD · Full-time · Direct hire · $125,000–$165,000 a year · Job ID 4f65adb2
My client seeks a Computational Protein Engineer to build and lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.
The ideal candidate will take on the following responsibilities:
- Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
- Drive protein expression, purification, and characterization workflows across multiple formats
- Design and execute binding and functional assays to evaluate and iterate on engineered proteins
- Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
- Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies
The ideal candidate will possess the following qualifications:
- PhD in biochemistry, molecular biology, protein biochemistry, or related discipline
- Hands-on expertise in protein expression, purification, and characterization
- Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
- Peer-reviewed publications and/or patents in antibody or protein engineering
- Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
- Proven ability to lead technical teams and manage complex, multi-faceted projects
- Outstanding written and verbal communication skills
This role is onsite in Rockville, MD.